Search results for " optimization"
Article
Cell-free Expression Systems Pose Cell Culture Alternative
Cell-free expression is promising in preclinical applications, but still presents challenges to scale up for commercial production.
Feliza Mirasol
Among the challenges in upstrea…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
In a pandemic, genetic vaccines offer several advantages over traditional approaches.
By Cynthia A. Challener
For a vaccine to be effective, the components of the disease o…
Article
Process Development: 2020 Reflections and 2021 Possibilities
Last year in particular reenforced the need to reapproach optimization and flexibility for all bioprocesses, as well as emphasized the importance of life-saving products such as vaccines.
To shed …
Article
Implementation of Process Intensification Strategies Across the Entire Cell Culture Workflow
Furthermore, the importance of cell culture media optimization prior to implementation of any new process will be discussed.
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Article
Monitoring and Control of Inline Dilution Processes
Buffer management has received less attention in process intensification despite the high costs and labor-, space-, time-, and material-intensive nature of this common downstream activity.
By…
Article
Design Considerations for a Commercial Cell and Gene Therapy Facility
The commercialization of cell and gene therapies has become a reality, prompting deeper considerations of logistics, technology, and design for manufacturing facilities.
By Feliza Mirasol
…
Poster
Perfusion Media Development for Scalable Processes
Cell culture perfusion processes are considered optimal for a truly integrated continuous biomanufacturing pipeline. The nutrient-rich but balanced media should be designed to support very low cell-sp…
Article
Moving PAT from Concept to Reality
The learning curve for process analytical technology has slowed widespread adoption.
By Cynthia A. Challener
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Process analytical technology (P…
Article
What’s New in Upstream Technologies
Recent upstream processing innovations include enhanced sensor technology, single-use bioreactors, and automated cell culture systems.
By Amber Lowry
SCIENCE PHOTO - STOCK.A…
Article
Science Focus Fuels Successful Process Development for Startups
There is no opportunity at that time for further process optimization, so it is important to be thoughtful about process development early on, according to Sharei.
Lastly, the quantity of effort r…