Search results for " sterile"
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
Before the sterile filtration step, the viral particles were concentrated and transferred into the final buffer by diafiltration using a ReadyToProcess hollow fiber cartridge (RTPUFP-500-C-9S). Finall…
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Bioprocess filter selection guide
Use this guide to quickly select the right filters for depth filtration, tangential flow filtration, sterile filtration, or virus filtration. The filters are available in a range of formats and scales…
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Single-Use Technologies Prove Effective for Viral Vector Process Development
At larger scales, disposable aseptic connectors do allow for autoclaved probes to be inserted into single-use vessels in a sterile manner outside of BSCs. These solutions, however, says Mohindra, are …
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Strategizing for Rapid Changeovers in Biologics Manufacturing
Olivier Le Moal/Stock.Adobe.com
By Cynthia A. Challener
Facility and equipment design are important, but the team and its experience matter most.
Through its Operation Warp Speed pro…
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New Therapies Present Scaling Challenges
New Therapies Present Scaling Challenges
Manufacturing differences between traditional mAb therapies and newer biotherapeutics dictate whether processes should be scaled up, scaled out, or use an al…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
“These large-volume-liquid BPCs are used as the primary source of sterile process liquids or as a second source/back-up supply to reduce demand on the customer’s in-house capabilities and capacities,”…
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Understanding Validation and Technical Transfer, Part 3
Understanding Validation and Technical Transfer, Part 3
Validation ensures safe and effective biologic products that benefit the patients whose health and wellbeing depend on the therapies. Part 1 |…
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Industry Adoption of Single-Use Systems Remains Low
Furthermore, if the bioprocess is classified as totally sterile, then vessels need to undergo an additional steam-in-place cycle, which can run another three hours or longer. The time used to prepare …
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Single-use Bioreactors Have Reached the Big Time
The company has also focused on developing single-use bioreactors that can interface with devices, such as cell retention devices, from different manufacturers and that contain sterile connections for…
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Continuous Manufacturing: A Changing Processing Paradigm
They also note that continuous capture typically requires sterile chromatography columns. “For downstream polishing steps, the infancy of multi-column chromatography systems is a limitation,” they add…