Search results for " modeling"
Article
High-Throughput Process Development in an Historical Environment
About 100 delegates from 13 different countries joined the discussions on HTPD case studies in upstream, downstream, and formulations, as well as modeling, data analysis, and analytics. A new session …
Article
Using Quality by Design to Develop Robust Chromatographic Methods
Here, experimental studies are combined with in-silico modeling software to maximize the value of the results by being able to predict between experimental parameters (15, 16).
Figure 3: Re…
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Predicting Progress in Protein Aggregation
Techniques to enable the design and formulation of stable, protein-based therapeutics.
In silico analysis and the evaluation of formulability, aided by new analytical tools such as hydrogen deut…
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Sterilization Trends for Single-Use Consumables
“Evolving technologies in digital modeling and dose-delivery mapping during the irradiation process are expected to help optimize the process. In silico techniques can model how boxes of SU systems ar…
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Top Process Development Trends for 2021 and a Look into 2022
Implementing Titers, Compliance, Mechanistic Modeling of Chromatography for Smarter Process Development
Bioprocessing has evolved over the past 30 years, and readers how curious how to navigate the…
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Improving Upstream Predictability
…pstream processing, from bioreactor design and media development to process control, automation, and modeling.
Some of the most significant gains have been made in cell line expression, adv…
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Advances in Engineering of Protein-Based APIs
Advanced modeling tools are enabling the rapid engineering of more complex proteins with desirable properties. Companies are also paying attention to the developability and manufacturability of protei…
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Scaling Up Novel Therapies
Use of digital modeling is helping developers understand processes at small scale and assess operations before scaling up, he says.
Bioreactors also present opportunities for scaling out…
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DoE Provides Benefits, but Preparation Is Necessary
Nov 1, 2014
By: Cynthia Challener, PhD
BioPharm International
Volume 11, Issue 27, pp. 28-29
Using a design-of-experiment (DoE) approach allows a formulation development scientist t…
Article
Continued Process Verification for Biopharma Manufacturing
The authors discuss complications of implementing continued process verification and provide recommended approaches.
Oct 1, 2014
By: Jeff Fleming, Robin Payne
BioPharm International
…