Search results for " MabSelect" in Articles / App Notes
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Detailed agenda for Chromatography + filtration virtual summit
We will also discuss recent innovations, such as Cytiva™ Protein Select™ technology, MabSelect™ VH3 resin, and MabSelect VL resin.
Registration is free of charge - see you there!
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Chromatography for the Diversified Antibody Pipeline
It may place more work on the main polishing steps, however, MabSelect may interact with the classes of DH3 in the antibodies—which enables separations targeting the constant DC region. We can see the…
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Sanitization Opportunities for Protein A Resins
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Bacterial endospores present a challenge in bioproduction due to their resistance to common sanitization procedures using high concentrations of NaOH. Several protein-b…
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Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
The process, performed with MabSelect™ PrismA Protein A chromatography resin, was scaled up 20-fold from a 70 mL HiScale™ 26 column to a 1400 mL AxiChrom™ 100 column. Equivalent mAb recovery and purit…
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Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
Several years ago, we started a development project to design and validate the next-generation protein A resin, MabSelect PrismA, which was just introduced to the market. Now, 1M NaOH can in fact be u…
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Optimizing KiH bispecific antibody chromatography steps
… Cytiva developed an optimized capture step for two closely related knob-into-hole (KiH) bsAbs using MabSelect PrismA™ protein A resin which reached a purity of 94%. In addition, two flow-through pol…
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Purification strategies for antibody-derived entities: bispecifics and fragments
The diversity of antibody variants in today’s pipeline presents unique challenges for purification. Purification platforms used for many monoclonal antibodies (mAbs) need to be adopted for ant…
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Top challenges in recombinant protein purification process development
…ent from mAbs, which do have a great affinity solution that can be used in protein A, such as Cytiva MabSelect PrismA. But then there's also a good platform approach that can be used. So after your a…
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Optimization of a two-step purification method for bispecific antibodies
Bispecific antibodies (bsAbs) have gained increasing interest over recent years because they can bind two antigens, offering unique modes of action compared to monoclonal antibodies. New and i…
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Capture of Bispecific Antibodies and Removal of Product-Related Impurities
In this article, Cytiva presents data on applications using MabSelect™ VL protein L resin with novel selectivity to purify challenging entities.
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