Search results for " mixing" in Articles / App Notes

Article Scaling Up Novel Therapies
“Challenges tend to come with scale-dependent parameters that are more difficult to mimic, such as mixing, heat transfer, and mass transfer,” he says.  High throughput There is still a…

Article Biopharma Says It Has an Evolution in New Technologies and Processes
Exhibitors announced new chromatography systems for pilot- and small-scale production, new resins, mixing systems, kits for glycan analysis and mycoplasma detection, filters, and sensors.    As bi…

Article Biopharmaceutical Market in Asia: Q&A with Günter Jagschies, Strategic Customer Relations Leader, Cytiva
This week, the Process Development Forum talks with Günter Jagschies, Strategic Customer Relations Leader, Cytiva, about the biopharmaceutical market in Asia.  The Asian market is most often s…

Article The New World of Biopharmaceutical Manufacturing
Industry experts discuss the single-use revolution and changes to upstream and downstream processing equipment. By Jennifer Markarian …

Article Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists. By Randi Hernandez When human cells travel throug…

Article Being Thorough When Transferring Technology
While mixing, heat transfer and oxygen transfer all become more challenging upon scale up, one of these may become controlling with scale. For example, when single-use bioreactors were a nascent techn…

Article Downstream Processing for Cell-Based Therapies
This in-situ detachment procedure should be scalable to larger, industrial-scale bioreactors, having been established on well-understood theoretical mixing principles. Moreover, given the detachment p…

Article Mechanistic Modeling of Preparative Ion-Exchange Chromatography
The mixing time of CSTR (τ1 τ2 τ3 τ4) are shown in Table II. The DPFR has length and dispersion coefficient as parameters. The system captures the extra column volume as well as the dispersion effect …

Article Impact of Manufacturing-Scale Freeze-Thaw Conditions on a mAb Solution
The objective of this study was to assess the impact of manufacturing-scale, freeze-thaw conditions on aggregation and subvisible particle formation of a monoclonal antibody solution (mAb-A; IgG1) u…

Article Evaluating E&L Studies for Single-Use Systems
Small-scale assembly extraction study The small-scale assembly option was applied to a fill/finish manufacturing process that involved the use of a single-use polyethylene mixing bag, steril…

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