Search results for " mixing" in Articles / App Notes
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
Consideration should be given to either proportional mixing of the raw material lots for each run or use of a statistical technique called blocking, which incorporates change of material lots into the…
Article
Under pressure: exploring root causes of leaks in single-use mixers
More minor issues, like buffer leaks during a mixing step, are less costly, but they still have an impact – increasing the time, material, and consumable use for that step.
Here we’ll take a look …
Article
Considerations in depth filter scale-up
Depth filters are widely used in the biopharmaceutical industry. They are typically made of a mixture of cellulose, filter aids, and a binder. These components can be milled and mixed in diffe…
Article
Discovering the unknown: How does in silico process development change PD scientists’ work?
In silico process development for chromatography is a paradigm-shifting approach that redefines the routine work of process development scientists. But what does it actually mean to perfor…
Article
Report from the 6th International HTPD Conference
Professor Micheletti presented a historical view on the origin of microwell plates, and how the understanding of the flow and mixing in individual cells on the plate has evolved, along with case studi…
Article
High-concentration monoclonal antibody drugs: manufacturing challenges
Manufacturing unit operations that are directly impacted by higher concentration formulations range from ultrafiltration to sterile filtration, filling, mixing and storage. Solutions that maintain qua…
Article
Chromatography for the Diversified Antibody Pipeline
CytivaVideo
In this video, Eva Heldin, Section Manager of Antibody Application in R&D at Cytiva is interviewed by BioPharm International and shares what antibody therapies are in the pipelin…
Article
mRNA: The messenger - LNP formulation
Join us for part 5 of mRNA: the messenger, where we discuss key considerations for the formulation of lipid nanoparticles (LNPs) for mRNA drug delivery, including mixing, encapsulation, polishing and …
Article
Adsorption isotherm models for chromatography
Read on commonly used models for the thermodynamics of adsorption within a chromatography column.
Indeed, in order to create a complete chromatography model, the adsorption of compon…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
Ram, meanwhile, would like to see improvements in mixing technologies for flatware used in seed trains or entirely new means of building up seed trains to achieve greater uniformity and consistency of…