Search results for " capacity"
Article
Flexibility in Biopharmaceutical Manufacturing
The ability to install capacity within a horizon of near certainty is a very valuable position to be in.
KEEPING UP WITH DEMAND
At plant level, capacity will have to be flexible not just to …
Article
Considerations in depth filter scale-up
The complex nature of the raw materials gives each filter a relatively broad pore size distribution and provides some adsorptive capacity through charge and hydrophobic interactions. The filter media …
Article
Evaluating the Use of Continuous Chromatography
…rations, continuous chromatography can offer significant productivity gains and increased production capacity, for example, through increased utilization of chromatography resin binding capacity, red…
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
At the same time, the production platform selected to manufacture clinical material must be scalable in order to enable the target capacity to be reached and promote cost-effectiveness. Adherent cell …
Article
Setting Up Bioprocessing Systems for Digital Transformation
Hahn points out that, for instance, pre-packed single-use chromatography columns of the same type may differ in terms of column packing and resin lot capacity. “In practical application, these differe…
Article
Innovative Chromatography Resins Can Improve Purity and Quality
…urther refined around key parameters, such as resolution, selectivity, pressure/flow properties, and capacity to ensure competitive downstream solutions into the future, Ihre says. “Such improvements…
Article
Technology Innovations Improve Process Chromatography Performance
“That dearth is seen especially through the limited dynamic binding capacity needed to process the high-titer cell culture harvest,” he says.
The performance reproducibility in column packing, whi…
Article
Best Practices for Selecting a Top-Quality Cell Line
The capacity of the cell line to cope with the secretory stresses associated with the high level of protein production, particularly with many of the newer, non-natural proteins such as bi-specifics o…
Article
Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Such was the viewpoint of one popular article, which explored some stumbling blocks to wider spread adoption of single-use systems in the biomanufacturing arena and how capacity needs are changing. …
Article
Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…