Search results for " cell" in Articles / App Notes
Article
Determining Criticality, Part Two: DoE and Data-Driven Criticality
For example, to perform a multivariate study on a fermentation unit operation, additional processing through cell lysis and purification unit operations is needed so that CQAs may be sampled and teste…
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Predicting Progress in Protein Aggregation
There are ongoing studies aimed at developing sophisticated cell-based assays for the evaluation of the immune response to protein aggregates, but despite some preliminary links between in vitro data …
Article
Best Practices in Adopting Single-Use Systems
Key considerations for implementing single-use components or platforms when moving from research to process development.
The adoption of single-use systems in biopharmaceutical production or…
Article
ReadyToProcess WAVE 25 Bioreactor System
The system is based on a well-known rocking technology that provides mixing and aeration to the culture, which is maintained in an inflated, disposable Cellbag bioreactor cultivation chamber.
With…
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Trends in Downstream Bioprocessing
It involves the removal of insoluble cell debris and particulates; product isolation through extraction, adsorption, ultrafiltration, or precipitation; product purification through affinity chromatogr…
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Essentials in Establishing and Using Design Space
Knowledge of product or process acceptance criterion is crucial in design space.
Design space is generally considered to be the areas where the product or process parameters can be run safe…
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Report from the Eighth International Plasma Product Biotechnology Meeting Melia Salinas, Lanzarote, Spain
One hypothesis discussed by Alan was that IVIg may interact with activating FcRs on dendritic cells in the initiation of its effects.
Jan Over from Sanquin gave an insightful presentation on…
Article
A Platform Approach for the Purification of Domain Antibodies (Dabs)
coli host cell proteins (ECP) and endotoxin levels.
Next, a polishing step using Capto MMC ImpRes further reduced ECP and endotoxin levels at yields of > 86%.
Finally, Capto adhere ImpRes …
Article
Biosimilars Development and Supply: How Complex Can the Process Be?
Unlike the development of small molecules, several bioanalytical assays are necessary in the early development of biologics, which are typically produced within engineered cells from pharmacologically…
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Prescribing Caution for Biosimilars
In statehouses around the country, lawmakers are beginning to address the complexities of cutting-edge biotech drugs and the regulatory issues related to the interchangeability of biosimilar medicin…