Search results for " cell"
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mAbs to Watch in 2016
The PD-L1 checkpoint inhibitor is being investigated for the treatment of various solid tumors, including indications for non-small cell lung cancer (NSCLC), bladder cancer, renal cell carcinoma, and …
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Bracing for a Future Wave of Advanced Therapies
Buoyed by the regulatory approval of several cell and gene therapy (CGT) products for difficult-to-treat diseases, the US biopharma industry is now bracing for a new wave of CGTs in the near future as…
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Top Process Development Trends for 2021 and a Look into 2022
Next-Generation Therapeutics: Improvements & Challenges
Advanced therapeutic medical products (ATMPs)—which are based on genes, tissues, or cells—continue to gain traction. They are further categor…
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Virus-like Particles as Therapeutic Moieties of the Future
At least 110 VLPs have been constructed so far from 30 different virus families (1), and a variety of expression systems ranging from bacteria to mammalian cell systems have been used for their produc…
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A Look at the Affinity Chromatography Landscape
…ein-based biologics, but a wide range of other biomolecules, from viral vectors and nucleic acids to cells.
Beyond impurity removal for “simple” proteins
Affinity chromatography in biologics …
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Would you please start by giving us a short overview of what are exosomes and the benefits they may have in clinical applications?
Exosomes are cell-derived vesicles produced by living cells and f…
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The New World of Biopharmaceutical Manufacturing
Single-use systems must be tested extensively to ensure that their materials of construction do not inhibit cell growth or release chemicals into the product stream during bioprocessing. Biomanufactur…
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N-Glycan Analysis of Biotherapeutic Proteins
For example, arguably the most common N-glycan structure present on mAbs made in Chinese hamster ovary (CHO) cells is G0F: asialo-, agalacto-, biantennary complex N-glycan, core-substituted with fucos…
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Being Thorough When Transferring Technology
Significant increases in cell mass have led to limitations with both technologies. Next-generation harvest technologies, including flocculation with cell settling and microfiltration, are being implem…
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Managing Biomanufacturing Capacity Expectations
According to numbers from the 2016 BioPlan report (1), approximately 59% of respondents used at least some outsourced capacity for mammalian cell culture, 55% used outsourcing for microbial fermentati…