Search results for " control"
Article
Cell-free Expression Systems Pose Cell Culture Alternative
The professors collectively believe that cell-free protein expression offers increased control and flexibility compared to traditional cell-based bioprocessing. DeLisa also emphasizes that “cell-free …
Article
Updating Viral Clearance for New Biologic Modalities
This is accomplished by controlling liquid flow during a VRF step based upon the pressure differential across the VRF filter itself, says Berrie. So far, he adds, this approach has improved overall pr…
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Technology Innovations Improve Process Chromatography Performance
… of single-use technologies, better characterization of raw materials, and the use of more precisely controlled bioreactors, improvements in downstream processing have not kept pace, says Nandu Deork…
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Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
Raw material quality control (QC) testing can also be reduced or eliminated by implementing single-use technologies, saving time from reduced process steps as well as labor costs.
The increa…
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Biomanufacturing: Demand for Continuous Bioprocessing Increasing
- Improved quality: Biological molecules are expressed continuously, and compared to batch culture, continuous culture tends to be more controllable, less intense and stressful, including less shear a…
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Cell-Culture Advances Test Bioreactor Performance Models
Some of the challenges with perfusion processes include sensor instability and fouling over the course of the culture, which impacts the ability to effectively monitor and control these processes, acc…
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Tools and Processes for Mature and Emerging Therapies
To control contamination threats during transfer and fill/finish steps for bulk, vial, and syringe filling, companies introduced improvements to existing technologies and processes such as restricted …
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Design Considerations for a Commercial Cell and Gene Therapy Facility
And then, finally, a digital solution encompassing electronic batch records, process monitoring, scheduling, and other key process attributes should be designed-in early to add efficiency and control …
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Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Factors that need to be analyzed and controlled for biosimilar development. (Figures courtesy of the authors)
Monoclonal antibodies (mAbs) are at present the fastest growing subclass of biophar…
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State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
• When asked a new question about what broader pharmaceutical industry small-molecule experience could benefit the biopharmaceutical industry, the leading three responses were "Process control, real-t…