Search results for " antibody"
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Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Since the first therapeutic antibody came onto the market in 1986, up to the end of 2014, 47 products have been approved in the United States or Europe for a number of diseases including various types…
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Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
Protein L resins bind to kappa light chain and are often used to purify antibody fragments such as dAbs and Fabs — but they can also be used to remove product-related impurities from bispecif…
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Paring Down Impurities in Downstream Processing
Myriad choices confront manufacturers before they even consider optimizing downstream processes. Each decision directly influences what final options will be available on arriving at the final…
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Digitalization: The Route to Biopharma 4.0
Process Analytical Technology in Continuous Processing: Model-based Real Time Control of pH Between Capture Chromatography and Viral Inactivation for Monoclonal Antibody Production. J Chromatogr A. 20…
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Western Blot Detection: Is Film or a Digital CCD Imager Better?
It is based on building an antibody:protein complex via specific binding of antibodies to proteins immobilized on a membrane and detecting the bound antibody with one of several detection methods.
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Scaling Up Novel Therapies
Scaling Up Novel Therapies
Platform processes have improved monoclonal antibody scale-up. Can they do the same for personalized therapies?
By Agnes S…
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Preclinical Evaluation of Product Related Impurities and Variants
Two case studies—one involving a microbial therapeutic product (granulocyte colony stimulating factor)—and other—a mammalian therapeutic monoclonal antibody (bevacizumab) have been used to illustrate …
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Unifying Continuous Biomanufacturing Operations
included the upstream and preliminary downstream steps of a monoclonal antibody (mAb) in 28 days, with the secondary downstream steps taking an additional two-and-a-half days (3).
A 1998 analysis …
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Continuous Processing for the Production of Biopharmaceuticals
There are only a few cases where an entire process has been developed and all are for monoclonal antibody production. Researchers have recently demonstrated the first integration of high-density perfu…
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mAbs to Watch in 2016
Brodalumab, however, will work a bit differently—it is an antibody that binds to the IL-17 receptor, whereas secukinumab and ixekizumab focus on the IL-17 ligand. In clinical trials, ixekizumab demons…