Search results for " recombinant" in Articles / App Notes
Article
Ensuring the Quality of Biologicals
Biologicals are those products derived from biological sources such as tissues and cell extracts, fermentation using micro-organisms, plasma, plants, or those produced by recombinant DNA technology. T…
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A Closer Look at Affinity Ligands
Today, Protein A ligand is manufactured and purified on a large scale using recombinant DNA technology. Purfied Protein A ligand is covalently coupled (conjugated) to a solid, porous support to form a…
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FAQs about Cytiva™ Protein Select™ technology
This FAQ page provides answers to a range of questions covering the mechanism, application, capabilities, and potential use cases of the resin and tag for purifying recombinant proteins.
Explore qu…
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Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
Recently, New England Biolabs, a provider of recombinant and native enzymes for molecular biology applications, completed an effort to redesign manufacturing of the most widely used analytical glycosi…
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Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Also, during this period, the number of FDA-approved recombinant therapeutics has increased by approximately 400% (6,7). In 2017, FDA set a record for the number (31 approvals) and percent (93%) of ap…
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Automation Trend in Fill/Finish Reduces Contamination Risk
The company installed the new filling line to meet demand for innovative biologics, including vaccines, gene therapies, oncolytic live virus-based therapies, monoclonal antibodies, and recombinant pro…
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Unifying Continuous Biomanufacturing Operations
“Typically, in antibody and most recombinant protein production, cell lines are very stable. Certain exceptions exist, and certainly, a few companies have published on enzyme-producing cell lines that…
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Downstream Processing for Cell-Based Therapies
In most cases, the process is likely to involve the use of an animal-free recombinant enzymatic dissociation reagent (such as recombinant trypsin) and some physical force exerted through an increase i…
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Continuous Processing for the Production of Biopharmaceuticals
In recent years, there have been publications reporting development of a fully integrated end-to-end commercial continuous process for the manufacturing of recombinant monoclonal antibodies (5).
T…
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Continuous Manufacturing: A Changing Processing Paradigm
The platform flows a liquid culture medium from a perfusion bioreactor into a preliminary multi-column chromatography system (MCCS1), then the eluate of the MCCS1 containing the recombinant therapeuti…