Search results for " production"
Article
Automated Buffer Preparation – Increasing Production Capacity While Maintaining Footprint
In fact, buffer preparation is known to be one of the most resource-intensive activities in biomanufacturing, as large volumes of buffers and process liquids are often required as production capacity …
Article
Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
The data show that the ADCF process using VaccineXpress for rotavirus propagation is scalable, promoting the production of infectious viral particles.
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Article
Case Study: Oncolytic Adenovirus Production
This case study describes a robust upstream process and downstream process for oncolytic adenovirus production. Purity of final samples meets regulatory requirements.
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Article
Faster Flavivirus Vaccine Production
Viral vaccines need to be produced fast and in large quantities. Routine immunizations and preventive campaigns, like stockpiling in response to emergencies, involve millions of doses, and speed is es…
Poster
A Scalable Adenovirus Production Process
To meet these needs, a process for adenovirus production, from upstream cell culture to downstream purification, using modern tools and technologies was developed.
The novel process is easily sc…
Article
Integrated Semi-Continuous Process for mAb Production
A complete process for the production of a biopharmaceutical consists of a great number of distinct unit operations, for example, cell culture, filtration, and chromatography. Linking these differen…
Article
Handbook: Design of Experiments in Protein Production and Purification
The focus is on DoE for protein production and puri cation but the theory can be applied in many other applications.
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Poster
Scale-up and process economy calculations of a dAb purification process using ready-to-use products
Purification of a domain antibody (dAb) in a chromatography capture step was successfully scaled from laboratory to pilot scale using ready-to-use equipment and ready-made buffers. The scaled-up pro…
Poster
Validation of Cytodex™ Gamma microcarrier-based virus production in single-use bioreactor systems
A majority of cell lines commonly used for viral vaccine production are anchorage-dependent and require expansion on solid surfaces. Here, we describe different approaches for the cultivation of Ver…
Poster
Modes of controlling charge variant distribution in Mab production
Charge variant distribution is a critical quality attribute for MAbs and is therefore of interest to monitor and control during the production process. In this study, we investigated the effects of ce…