Search results for " monoclonal" in Articles / App Notes
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
A typical monoclonal antibody (mAb) process may require 2000 L of a buffer and more than 100,000 L per batch based on titer and bioreactor volume (1, 2). As a result, the variety of buffer solutions u…
Article
Next Generation Process Chromatography
This is true for monoclonal antibodies (mAbs) that present the modern age in terms of fighting diseases such as cancer and autoimmune conditions. It is also true for gene therapies, which could be con…
Article
Step Up to GMP Manufacturing or Outsource to a CDMO: Considerations and Tips
Whether you are developing a new monoclonal antibody (mAb), cell therapy, gene therapy, or large-molecule biologic drug, the decision to tackle GMP manufacturing in-house or work with a contract devel…
Article
Gene Therapies Push Viral Vector Production
Furthermore, it will be interesting to see the developments in the intensification of monoclonal antibody (mAb) production processes. Lessons learned and technologies developed here could have the sam…
Article
Speeding Up mAb Purification Using Fiber-based Technology
Learn how to automate high throughput monoclonal antibody (mAb) purification and improve throughput significantly using fiber-based chromatography.
With purification cycles in minutes rather th…
Article
Rapid Cycling Protein A-Based Fiber Chromatography to Address Emerging Downstream Bottlenecks
This structure allows high monoclonal antibody (mAb) binding capacities at very short residence times, which reduces cycle times to minutes instead of the hours needed for resin-based chromatography. …
Article
Improving Upstream Predictability
Better understanding and control of cell behavior is yielding benefits, upstream and beyond.
By Agnes Shanley
In the earliest days of biotech, developers often struggled to sust…
Article
Flexible Facilities for Viral Vector Manufacturing
While the initial project looked at a monoclonal antibody (mAb) facility, the team plans to extend the concept to cell and gene therapy production.
Cytiva has amassed expertise in modular design a…
Article
Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
With the exception of a few “blockbuster” monoclonal antibody products, which are better suited to large-scale stainless-steel bioreactor production, most biopharmaceutical companies are now increasin…
Article
Epitope Binning: A Critical Step in Antibody Selection
Read about how surface plasmon resonance (SPR) is used to characterize closely related “bins” of monoclonal antibodies (mAbs) targeting the same epitope of the target protein, and how the selection …