This application note describes the performance of single-use Xcellerex XDM Quad Mixing System used as a slurry tank when packing chromatography columns. The capability of the mixing system to keep the chromatography medium (resin) in suspension and the possibility to integrate the system in column packing were studied. Further, an evaluation of the effect of the integrated, disposable mixer bag impeller on chromatography media particles was performed. The results show that XDM Quad Mixing System is suitable for use as a chromatography media slurry tank when packing columns.
October 8, 2015